This research article has been published in the Jordan Journal of Pharmaceutical Sciences.

ABSTRACT 

Prenatal stress detrimentally impacts cognition, behavior, and psychosocial traits. Tinospora cordifolia (TC) is known for its antistress and cognitive enhancement properties. However, its effectiveness against stress induced by maternal separation and vibration is not well-documented. The purpose of the study was to assess the neuroprotective effects of TC on neonatal rats who experienced prenatal vibration stress and stress caused by maternal separation. Pregnant Wistar rats in the stressed group experienced three hours of daily vibration stress from 7–16 days of gestation. The treatment group was given 6 mg/kg of TC extract before vibration stress. The neonates were separated from their mother and treated with TC postnatally. At the end of the treatment period, the rats were subjected to a spatial learning task. Following this, animal brains were processed for Golgi staining to study the CA3 neuronal arborization. TC-treated mothers showed significantly better spatial learning than those subjected to vibration stress alone. Neonates exposed to prenatal stress took longer to find the target quadrant, indicating impaired spatial memory, which improved with TC treatment. Increased dendritic branching in CA3 neurons was observed in both TC-treated mothers and neonates. TC extract improves spatial learning in rats by attenuating hippocampal CA3 neural damage induced by prenatal vibration stress and maternal separation.

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Authors: 

Ashwini LS; Mohandas Rao KG; Kiranmai S Rai; Somashekar Shetty B; Guruprasad Rao; Padmanabha Udupa; Chinmay Ajit Suryavanshi

 Citation: 
Ashwini LS, Rao KGM, Rai KS, Shetty BS, Rao G, Udupa P, Suryavanshi CA. (2025). Neuroprotective Potential of Tinospora cordifolia in Attenuating Hippocampal CA3 Neuronal Damage in Pregnant Wistar Rats and their Neonates Exposed to Prenatal Vibration Stress and Maternal Separation. Jordan Journal of Pharmaceutical Sciences, 18(4). https://doi.org/10.3516/jjps.v18i4.3141

Read the article: 

https://doi.org/10.1152/advan.00240.2025

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